2048 Ventures is a thesis-driven earliest stage venture capital firm based in NYC and Boston. The firm leads pre-seed and seed rounds in Vertical AI, Deep Tech, Health, and Bio startups across the US and Canada, writing $500K–$3M checks.
Deal activity increased 100% year-over-year (6 deals in the last 12 months). Their most common stage is seed (40% of deals). Average disclosed round size is $15.0M (across 52 rounds with reported amounts).
Portfolio
45
Fund Size
$82.0M
Top Stage
Seed
Last 12 Mo
6
Team
Portfolio Breakdown
Stage Distribution
Sector Distribution
Investment Activity
DealsAvg Round Size
Portfolio
57 investments
| Company | Round | Amount | Date |
|---|---|---|---|
 Genius AI | Series D | $125M | Jul 2026 |
 Nebex | Seed | $30M | Jun 2026 |
| RRely Intelligence | Seed | $4.5M | May 2026 |
 Rely | Seed | $4.5M | May 2026 |
 Century Health | Seed | $5M | May 2026 |
 TwoStep Therapeutics | Series A | $21.1M | Jan 2026 |
| Genius AI | Series D | $44M | Jan 2026 |
 Pageport | Seed | $3.3M | Aug 2025 |
 H2Ok Innovations | Series A | $12.4M | Jul 2025 |
 Nionyx Bio | Seed | $4M | Jan 2025 |
| PPersist | Series A | $12M | Jan 2025 |
| H2Ok Innovations | Series A | $12.4M | Jan 2025 |
 Impilo | Series A | $11.5M | Nov 2024 |
 Nomic Bio | Series B | $42M | Jan 2024 |
 Persist AI | Seed | $4M | Aug 2023 |
| FFemTherapeutics, Inc. | Seed | — | May 2023 |
 Daily Blends | Seed | $2M | Mar 2023 |
| FFemTherapeutics, Inc. | Unknown | $1.9M | Jan 2023 |
 Impacked | Seed | $2.5M | Nov 2022 |
 Airspace | Series B | $23M | Jun 2022 |
 Walnut | Series A | $110M | May 2022 |
 Soona | Series B | $35M | Jan 2022 |
 Arrow | Series A | $110M | Jan 2022 |
 Airspace Link | Series B | $23M | Jan 2022 |
 PainWorth | Seed | $1.7M | Dec 2021 |
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Top Co-Investors
Techstars9 shared
Y Combinator6 shared
Matchstick Ventures5 shared
Knoll Ventures3 shared
Construct Venture3 shared
Dynamo3 shared
Pioneer Fund3 shared
Innospark Ventures3 shared
Better Tomorrow Ventures3 shared
Plug and Play Tech Center3 shared
Lux Capital3 shared
LiveOak Venture Partners2 shared
Scale Venture Partners2 shared
Tensility Venture Partners2 shared
Goodwater Capital2 shared
Banana Capital2 shared
Company Ventures2 shared
Weekend Fund2 shared
Gradient Ventures2 shared
Afore Capital2 shared
Last updated: 7 October 2026