AIHealthcareGovernment & CivicMobility & TransportationFintechBiotech & Life SciencesManufacturingData & AnalyticsLogistics & Supply ChainE-Commerce & Marketplace
Ascend Venture Capital (St. Louis) focuses on early-stage, mission-critical, data-centric tech companies, particularly in AI/ML, SaaS, and commercial products, with a strategic emphasis on the Midwest. Their strategy involves rigorous due diligence and a methodical, human-centered approach to pre-Series A investments.
Deal activity increased 50% year-over-year (3 deals in the last 12 months). Average disclosed round size is $31.1M (across 13 rounds with reported amounts).
Portfolio
14
Fund Size
—
Top Stage
Seed
Last 12 Mo
3
Portfolio Breakdown
Stage Distribution
Sector Distribution
Investment Activity
DealsAvg Round Size
Portfolio
14 investments
| Company | Round | Amount | Date |
|---|---|---|---|
 Overland AI | Series D | $100M | Feb 2026 |
 Govstream.ai | Seed | $3.6M | Dec 2025 |
 Pionix | Seed | $8M | Nov 2025 |
| Overland AI | Series A | $32M | Jan 2025 |
| LLeap Financial | Seed | $3.5M | Dec 2024 |
 Clarity | Seed | $16M | Feb 2024 |
| PPIUR IMAGING | Series A | $4.9M | Jul 2023 |
 Xembly | Series A | $15M | Oct 2022 |
 Elation Health | Series D | $50M | Jul 2022 |
 Prometheus Biosciences | Growth | $130M | Nov 2020 |
| TTactoTek | Series B | $23M | Feb 2018 |
 Whalesync | Pre-Seed | $1.8M | — |
 FreightWaves | Series B | $16M | — |
 Fabric | Unknown | — | — |
Top Co-Investors
8VC3 shared
Point72 Ventures3 shared
Norwest Venture Partners2 shared
Shasta2 shared
Overmatch2 shared
Walden Catalyst1 shared
Bessemer Venture Partners1 shared
Secret Chord Ventures1 shared
Flying Fish1 shared
Fuel Ventures1 shared
Y Combinator1 shared
Liquid 2 Ventures1 shared
Soma Capital1 shared
Pale Blue Dot1 shared
Axeleo1 shared
Lightspeed Venture Partners1 shared
Seven Peaks Ventures1 shared
Flex1 shared
Triangle Peak Partners1 shared
Valor Equity Partners1 shared
Last updated: 16 April 2026