Yosemite is an oncology-focused venture capital firm founded by Reed Jobs in 2023, spun out of the Emerson Collective. The firm invests in early-stage cancer-focused companies and provides philanthropic grants to academic researchers, aiming to make cancer non-lethal within our lifetime.
58% of their portfolio is in Healthcare. Deal activity increased 50% year-over-year (9 deals in the last 12 months). Average disclosed round size is $49.7M (across 22 rounds with reported amounts).
Portfolio
15
Fund Size
$200M
Top Stage
Series A
Last 12 Mo
9
Team
DM
Daniel McHugh
Lead of the investment team
MB
Matt Bettonville
Investor
Portfolio Breakdown
Stage Distribution
Sector Distribution
Investment Activity
DealsAvg Round Size
Portfolio
26 investments
| Company | Round | Amount | Date |
|---|---|---|---|
 Solve Therapeutics | Bridge | $120M | Sep 2026 |
| TTurquoise | Series C | $40M | Mar 2026 |
 Turquoise Health | Series C | $40M | Mar 2026 |
 Ten63 | Unknown | — | Feb 2026 |
| Solve Therapeutics | Unknown | $120M | Jan 2026 |
 Chai Discovery | Series B | $130M | Dec 2025 |
| Solve Therapeutics | Series D | $120M | Nov 2025 |
 Sage | Series A | $20M | Oct 2025 |
 Fourier | Seed | $8.4M | Oct 2025 |
 Sage Care | Unknown | $20M | Oct 2025 |
 Daymark Health | Series A | $20M | Sep 2025 |
| DDaymark | Series A | $20M | Sep 2025 |
| Chai Discovery | Series A | — | Aug 2025 |
| DDaymark | Seed | $11.5M | Apr 2025 |
| Daymark Health | Seed | $11.5M | Apr 2025 |
 Tune Therapeutics | Series D | — | Jan 2025 |
| DDaymark | Series A | $20M | Jan 2025 |
 Shinobi Therapeutics | Series A | — | Aug 2024 |
| Turquoise Health | Series B | $30M | Jan 2024 |
| TTurquoise | Series B | $30M | Jan 2024 |
| Shinobi Therapeutics | Series A | $51M | Dec 2023 |
 Maia Oncology | Seed | $4.3M | Dec 2023 |
| Solve Therapeutics | Series A | $126M | Dec 2022 |
| Tune Therapeutics | Series B | $40M | Dec 2021 |
 Azalea Therapeutics | Series A | $65M | — |
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Top Co-Investors
Alexandria Venture Investments6 shared
Maverick Ventures5 shared
Oncology Ventures5 shared
SV Angel4 shared
SymBiosis4 shared
Abingworth LLP4 shared
Adams Street Partners4 shared
Andreessen Horowitz4 shared
General Catalyst3 shared
Oak HC/FT3 shared
The Blue Venture Fund3 shared
Healthier Capital3 shared
B Capital3 shared
Ally Bridge Group3 shared
Balyasny Asset Management3 shared
Menlo Ventures2 shared
Dimension2 shared
OpenAI Startup Fund2 shared
Neo2 shared
Last updated: 20 October 2026