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645 Ventures is an early-stage venture capital firm that primarily invests in enterprise software, including SaaS, developer tools, and infrastructure platforms, with selective investments in consumer technology and crypto/Web3. Their strategy involves a research-driven, founder-focused approach, leveraging proprietary software for deal sourcing and providing extensive support to help portfolio companies scale from Seed and Series A to growth stages.
Deal activity increased 175% year-over-year (11 deals in the last 12 months). Average disclosed round size is $41.7M (across 28 rounds with reported amounts).
Portfolio
31
Fund Size
$550M
Top Stage
Series A
Last 12 Mo
11
Team
Portfolio Breakdown
Stage Distribution
Sector Distribution
Investment Activity
DealsAvg Round Size
Portfolio
31 investments
| Company | Round | Amount | Date |
|---|---|---|---|
 Variance | Series A | $21.5M | Apr 2026 |
| UUptiq | Series B | $25M | Feb 2026 |
| PPelgo | Seed | $5.5M | Feb 2026 |
 Arbor | Seed | $6.3M | Feb 2026 |
 Risotto | Seed | $10M | Jan 2026 |
 Sequence | Series B | $20M | Dec 2025 |
| CClerq | Series A | $21M | Oct 2025 |
 Strella | Series A | $14M | Oct 2025 |
 Shift5 | Series C | $75M | Sep 2025 |
 Forterra | Series C | $238M | May 2025 |
 True Anomaly, Inc. | Series C | $260M | Apr 2025 |
 Shop Circle | Series B | $60M | Feb 2025 |
 Edera | Series A | $15M | Feb 2025 |
| Edera | Seed | $5M | Sep 2024 |
 Agency AI | Pre-Seed | $2.6M | Aug 2024 |
| True Anomaly, Inc. | Series D | $100M | Dec 2023 |
| Shop Circle | Series A | $120M | Sep 2023 |
 0pass | Seed | $3.5M | Jun 2023 |
 Setpoint | Series A | $43M | Dec 2022 |
| Shop Circle | Series A | — | Jun 2022 |
 Lunchbox | Series B | $50M | Feb 2022 |
 Genially | Series B | — | Sep 2021 |
 Apty Inc. | Series A | $7.5M | Jul 2021 |
 DeepSource | Seed | $2.6M | Jun 2020 |
| LLoverly | Unknown | $2M | Mar 2016 |
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Top Co-Investors
Y Combinator5 shared
Eniac Ventures4 shared
NFX3 shared
QED Investors3 shared
Decibel2 shared
Urban Innovation Fund2 shared
Okta2 shared
firstminute capital2 shared
i80 Group2 shared
FPV Ventures2 shared
Precursor Ventures2 shared
Rosecliff Ventures2 shared
Andreessen Horowitz2 shared
Eclipse Ventures2 shared
Menlo Ventures2 shared
ACME Capital2 shared
Champion Hill Ventures2 shared
Narya2 shared
Moore Strategic Ventures2 shared
Hedosophia2 shared
Last updated: 10 April 2026