America's Frontier Fund
America's Frontier Fund is a national security-focused venture capital firm that backs founders building frontier technologies critical to America's future, including advanced manufacturing, microelectronics, AI, energy, and biotech. The firm aligns private capital with U.S. sovereign priorities and invests across early to growth stages.
40% of their portfolio is in Biotech & Life Sciences. Deal activity increased 100% year-over-year (2 deals in the last 12 months). Their most common stage is series-a (40% of deals). Average disclosed round size is $29.2M (across 4 rounds with reported amounts).
Portfolio
5
Fund Size
$315M
Top Stage
Series A
Last 12 Mo
1
Team
Brian Wilcove
Managing Partner
Gilman Louie
Managing Partner
Jeff Karras
General Partner
Marianne Winkler
CFO & General Partner
Mike Mettler
General Partner
Steve Weinstein
General Partner
John Watters
Venture Partner
Kevin McGinnis
Partner
Aneesh Mdhekar
Analyst
Brian Connor
Operations Manager
Sabrina Rosahan
Executive Direcor, AFF
Portfolio Breakdown
Stage Distribution
Sector Distribution
Investment Activity
Portfolio
| Company | Round | Amount | Date |
|---|---|---|---|
 Antheia | Series C | $24M | Jan 2026 |
| RRevalia Bio, Inc. | Seed | $14.5M | Sep 2025 |
| TTacta Systems | Series A | $64M | Jun 2025 |
 revalia-bio | Seed | $14.5M | Jan 2025 |
 Tacta | Series A | — | — |
Top Co-Investors
Last updated: 8 September 2026