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Main Sequence is a venture capital firm that focuses on investing in deep technology companies translating Australian research into global businesses, aiming to solve major global challenges like decarbonization and feeding a growing population. Their strategy involves early-stage investments (seed to Series B) and a "venture science" model, actively partnering with researchers and universities to build companies from scientific discoveries.
They made 6 investments in the last 12 months. Average disclosed round size is $24.7M (across 24 rounds with reported amounts).
Portfolio
24
Fund Size
$1B
Top Stage
Series A
Last 12 Mo
6
Portfolio Breakdown
Stage Distribution
Sector Distribution
Investment Activity
DealsAvg Round Size
Portfolio
24 investments
| Company | Round | Amount | Date |
|---|---|---|---|
 Advanced Navigation | Series C | $102.7M | Mar 2026 |
 Breaker | Seed | $6M | Feb 2026 |
 Kasada | Series B | $20M | Feb 2026 |
 The Every Company | Series D | $55M | Nov 2025 |
 Uluu | Series A | $16M | Oct 2025 |
| MMorse Micro | Series C | $59M | Sep 2025 |
| AAvarni | Seed | $1.6M | Nov 2023 |
 JDoodle | Seed | $2.2M | Jun 2023 |
| EEndua | Seed | $7.8M | May 2023 |
| FFivecast | Series A | $20M | Apr 2023 |
| Uluu | Seed | $5.3M | Nov 2022 |
| SSamsara Eco | Series A | $34.7M | Nov 2022 |
| NNourish Ingredients | Series A | $28.6M | Oct 2022 |
 Lumachain | Series A | $19.5M | Aug 2022 |
 RIOS Intelligent Machines, Inc. | Series A | $28M | Feb 2022 |
 Q-CTRL | Series B | $25M | Nov 2021 |
 v2Food | Series B | $45M | Aug 2021 |
| MMGA Thermal | Seed | $5.9M | Aug 2021 |
| BBaraja | Series B | $31M | Mar 2021 |
| Kasada | Series B | $10M | Jun 2020 |
| Q-CTRL | Series A | $15M | Sep 2019 |
| EEmesent | Seed | $2.5M | Nov 2018 |
| GGilmour Space | Unknown | $36M | — |
 Myriota | Series A | $15M | — |
Top Co-Investors
Horizon Ventures3 shared
Blackbird3 shared
Hostplus3 shared
TenEleven Ventures3 shared
Square Peg Capital2 shared
Sierra Ventures2 shared
DCVC2 shared
In-Q-Tel2 shared
Bessemer Venture Partners2 shared
Reinventure2 shared
Airbus Ventures1 shared
Sequoia China1 shared
Burda Principal Investments1 shared
Startmate1 shared
Trinity Ventures1 shared
Astanor1 shared
HESTA1 shared
Regal1 shared
McWin1 shared
Last updated: 16 April 2026