OS Fund is a venture capital fund founded by Bryan Johnson in 2014 that invests in entrepreneurs, inventors, and scientists using applied intelligence to commercialize breakthrough discoveries in genomics, synthetic biology, diagnostics, and advanced materials. The firm aims to back platform-level science innovations that 'rewrite the operating systems of life.'
75% of their portfolio is in Biotech & Life Sciences. Average disclosed round size is $32.9M (across 10 rounds with reported amounts).
Portfolio
10
Fund Size
$100M
Top Stage
Series A
Last 12 Mo
0
Team
LK
Lily Kim, PhD
General Partner
JK
Jeff Klunzinger
Managing Director
BK
Brendan Kelly, PhD
Healthcare Venture Investments
BJ
Bryan Johnson
Founder
Portfolio Breakdown
Stage Distribution
Investment Activity
DealsAvg Round Size
Portfolio
12 investments
| Company | Round | Amount | Date |
|---|---|---|---|
 Viridos | Series A | $25M | Mar 2023 |
 Arzeda | Series B | $33M | Mar 2022 |
 Synthego | Series C | $110M | Oct 2018 |
 Verge Genomics | Series A | — | Jul 2018 |
 Lygos Inc | Series A | $13M | Dec 2016 |
| 33scan | Series B | $14M | Jul 2016 |
 Ginkgo Bioworks | Series B | $45M | Jul 2015 |
| Ginkgo Bioworks | Series A | $9M | Mar 2015 |
| Synthego | Unknown | — | — |
 A-Alpha Bio | Seed | $22.4M | — |
 Numat | Unknown | $12.4M | — |
 Emulate | Series B | $45M | — |
Top Co-Investors
Founders Fund3 shared
Felicis2 shared
8VC2 shared
Menlo Ventures2 shared
Y Combinator2 shared
Breakout Ventures2 shared
Novastar Ventures1 shared
Gobi Partners1 shared
DCVC1 shared
Canvas Prime1 shared
Casdin Capital1 shared
Jungle Ventures1 shared
Lewis & Clark AgriFood1 shared
Citi Ventures1 shared
Context Ventures1 shared
Blume Ventures1 shared
Circularity Capital1 shared
Bioeconomy Capital1 shared
Lifeforce Capital1 shared
Last updated: 9 September 2026