Two Sigma Ventures is an early to growth-stage venture capital firm that invests in transformative companies leveraging data science, machine learning, and advanced computing power across diverse sectors like enterprise software, fintech, and techbio. Their strategy involves providing capital, expertise, and a broad network to entrepreneurs building data-driven businesses.
Average disclosed round size is $71.9M (across 64 rounds with reported amounts).
Portfolio
66
Fund Size
$400M
Top Stage
Series A
Last 12 Mo
4
Portfolio Breakdown
Stage Distribution
Sector Distribution
Investment Activity
DealsAvg Round Size
Portfolio
66 investments
| Company | Round | Amount | Date |
|---|---|---|---|
 Freeform | Series B | $67M | Feb 2026 |
 Gameto | Series C | $44M | Aug 2025 |
 Bedrock Robotics | Series C | $80M | Jul 2025 |
 Cerby | Series B | $40M | May 2025 |
 Distributional | Series A | $19M | Oct 2024 |
 Crossover Markets | Series A | $12M | Jun 2024 |
| Gameto | Series B | $33M | May 2024 |
| XXaira Therapeutics | Growth | $1B | Apr 2024 |
| CCosmos Innovation | Series A | $19.7M | Oct 2023 |
| Cerby | Series A | $17M | Aug 2023 |
 NetBox Labs | Series A | $20M | Apr 2023 |
 Crossover Markets Group, Inc. | Seed | — | Mar 2023 |
 Crux | Growth | $50M | Jan 2023 |
 Rive | Series A | $10M | Jan 2023 |
 Tive | Series B | $54M | Apr 2022 |
 Remote | Series C | $300M | Apr 2022 |
 Terray Therapeutics | Series A | $60M | Feb 2022 |
 Radar | Series C | $55M | Feb 2022 |
 Mio | Series A | $8.7M | Dec 2021 |
 NewtonX | Series B | $32M | Dec 2021 |
 Comet | Series B | $50M | Nov 2021 |
 Anomalo | Series A | $33M | Oct 2021 |
 Nelo | Series A | $20M | Oct 2021 |
| SSora | Series A | $14M | Aug 2021 |
| Remote | Series B | $150M | Jul 2021 |
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Top Co-Investors
Accel6 shared
Sequoia Capital5 shared
NEA (New Enterprise Associates)5 shared
Foundry Group4 shared
Madrona Venture Group3 shared
Index Ventures3 shared
General Catalyst3 shared
CRV (Charles River Ventures)3 shared
Insight Partners3 shared
Redpoint Ventures3 shared
Trilogy Equity Partners3 shared
Salesforce3 shared
Lux Capital3 shared
Obvious Ventures3 shared
Khosla Ventures3 shared
First Round Capital3 shared
Scale Venture Partners3 shared
Susa Ventures3 shared
Accomplice2 shared
Goldman Sachs2 shared
Last updated: 13 March 2026