Freeflow Ventures is an early-stage venture capital firm focused on deep tech solutions to human and planetary health challenges, enabled by AI and ML. The firm invests in science-driven companies originating from Caltech and Berkeley.
38% of their portfolio is in Biotech & Life Sciences. Deal activity increased 100% year-over-year (2 deals in the last 12 months). Their most common stage is seed (46% of deals). Average disclosed round size is $12.0M (across 13 rounds with reported amounts).
Portfolio
12
Fund Size
$90M
Top Stage
Seed
Last 12 Mo
2
Team
DF
David Fleck
Founder & Managing Partner
SR
Steve Roy
Operating Partner
Portfolio Breakdown
Stage Distribution
Sector Distribution
Investment Activity
DealsAvg Round Size
Portfolio
13 investments
| Company | Round | Amount | Date |
|---|---|---|---|
 ERG Bio | Seed | $6.5M | Nov 2025 |
 PINC Technologies Inc. | Seed | $6.8M | Oct 2025 |
 Mitico | Seed | $4.3M | Feb 2025 |
 Tierra Biosciences | Series A | $11.4M | Mar 2024 |
 Holoclara | Series A | $16M | Jan 2024 |
 Membrion | Series B | $7M | Jan 2023 |
 H2U Technologies | Series A | $11M | Mar 2022 |
 Hydrosat | Seed | $10M | Nov 2021 |
| H2U Technologies | Series A | $7M | Jan 2021 |
 Aralez Bio | Series A | $12M | — |
 Appia Bio | Series A | $52M | — |
 StrokeDx | Seed | $5M | — |
 Miist Therapeutics | Seed | $7M | — |
Top Co-Investors
Expon Capital1 shared
Cultivation Capital1 shared
OTB Ventures1 shared
Santa Barbara Venture Partners1 shared
Plug and Play Tech Center1 shared
Azolla Ventures1 shared
Chevron Technology Ventures1 shared
Quantonation1 shared
Bisk Ventures1 shared
SOSV1 shared
APY Ventures1 shared
Safar Partners1 shared
Terra Venture Partners1 shared
Giant Step Capital1 shared
TCA Venture Group1 shared
Horizons Ventures1 shared
Bold Capital Partners1 shared
Material Impact1 shared
Creative Ventures1 shared
Hillspire1 shared
Last updated: 8 September 2026