Osage University Partners (OUP) is a venture capital firm that invests in science-driven startups emerging from the world's leading research labs and innovation ecosystems. Founded in 2009 and headquartered in Bala Cynwyd, Pennsylvania, OUP manages over $800 million and has invested in more than 150 life science and technology startups.
34% of their portfolio is in Biotech & Life Sciences. Deal activity increased 400% year-over-year (5 deals in the last 12 months). Average disclosed round size is $56.6M (across 85 rounds with reported amounts).
Portfolio
76
Fund Size
$800M
Top Stage
Series B
Last 12 Mo
3
Team
Matt Cohen
Managing Partner
Portfolio Breakdown
Stage Distribution
Sector Distribution
Investment Activity
DealsAvg Round Size
Portfolio
91 investments
| Company | Round | Amount | Date |
|---|---|---|---|
| TTerremoto Biosciences | Series C | $108M | Apr 2026 |
 Precede Biosciences | Series B | $63.5M | Jan 2026 |
 Addition Therapeutics | Unknown | $100M | Dec 2025 |
 Neuros Medical | Series D | $56M | Jul 2025 |
 Neuros | Series D | $56M | Jul 2025 |
 Atsena Therapeutics | Series C | $150M | Apr 2025 |
 Overland AI | Series A | $32M | Jan 2025 |
| Neuros | Unknown | $56M | Jan 2025 |
| Atsena Therapeutics | Series C | $150M | Jan 2025 |
 Quintessent | Seed | $11.5M | Mar 2024 |
| Precede Biosciences | Series A | $57M | Oct 2023 |
 Kate | Series A | $51M | Jun 2023 |
 Chroma Medicine | Series B | $135M | Mar 2023 |
 Hack The Box | Series C | $55M | Jan 2023 |
 Opsys | Series C | $51.5M | Jan 2023 |
 MicroTransponder | Series E | $73M | Sep 2022 |
| DDelfi Diagnostics, Inc. | Series B | — | Jul 2022 |
 Delfi | Series B | — | Jul 2022 |
| MicroTransponder | Series E | $53M | Jun 2022 |
| Delfi | Series B | $225M | Jan 2022 |
 Corelight | Series D | $75M | Sep 2021 |
 Sonoma Biotherapeutics | Series B | $265M | Aug 2021 |
 Glyphic Biotechnologies | Seed | $6.0M | Jul 2021 |
 Interius BioTherapeutics | Series A | $76M | May 2021 |
| Hack The Box | Series A | $10.6M | Apr 2021 |
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Top Co-Investors
OrbiMed12 shared
RA Capital Management11 shared
Alexandria Venture Investments8 shared
Canaan Partners8 shared
Sofinnova Partners7 shared
Illumina Ventures6 shared
Abingworth LLP6 shared
Frazier Healthcare Partners6 shared
New Enterprise Associates6 shared
Wellington Management5 shared
Cormorant Asset Management5 shared
U.S. Venture Partners5 shared
F-Prime Capital5 shared
Lightstone Ventures5 shared
Cowen Healthcare Investments5 shared
Northpond Ventures5 shared
T. Rowe Price4 shared
ARCH Venture Partners4 shared
Agent Capital4 shared
Pfizer Ventures4 shared
Last updated: 7 September 2026