Aperture Venture Partners is a New York-based venture capital firm focused on healthcare and life sciences investments, including medical devices, pharmaceuticals, healthcare IT/services, and diagnostics. The firm works with exceptional entrepreneurs to build innovative companies addressing unmet clinical needs.
38% of their portfolio is in Healthcare. Deal activity decreased year-over-year (2 deals in the last 12 months vs 5 prior). Average disclosed round size is $38.9M (across 46 rounds with reported amounts).
Portfolio
46
Fund Size
—
Top Stage
Series A
Last 12 Mo
2
Team
EH
Eric H. Sillman
PE
Paul E. Tierney, Jr.
Portfolio Breakdown
Stage Distribution
Sector Distribution
Investment Activity
DealsAvg Round Size
Portfolio
60 investments
| Company | Round | Amount | Date |
|---|---|---|---|
 Tangible | Seed | $4.3M | Feb 2026 |
 Ex Nunc Intelligence | Pre-Seed | $2.1M | Jan 2026 |
| AallO | Series A | — | Jan 2026 |
 Tangible Finance | Seed | $4.3M | Jan 2026 |
 Neuros Medical | Series D | $56M | Jul 2025 |
 Neuros | Series D | $56M | Jul 2025 |
 Shoulder Innovations | Series E | $40M | Mar 2025 |
| Neuros | Series A | $56M | Jan 2025 |
| Shoulder Innovations | Series E | $40M | Jan 2025 |
 Cyder | Pre-Seed | $1.1M | Dec 2024 |
 Fundcraft | Series A | — | Nov 2024 |
 Trustap | Unknown | — | Jul 2024 |
| Fundcraft | Series A | — | May 2024 |
 Alaffia | Series A | $10M | Apr 2024 |
 Nalu | Series E | $65M | Mar 2024 |
 Groov | Seed | — | Jan 2024 |
 ShiraTronics, Inc | Series B | $66M | Jan 2024 |
| Alaffia | Series A | $10M | Jan 2024 |
| Nalu | Series E | $85M | Jan 2024 |
 Kayna | Pre-Seed | — | Sep 2023 |
 Pryon | Series B | $100M | Sep 2023 |
 Cortica | Growth | $75M | Apr 2023 |
| Cortica | Series D | $75M | Apr 2023 |
| CCortica Care | Unknown | $75M | Jan 2023 |
 XII Medical | Series A | $30M | May 2022 |
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Top Co-Investors
Longitude Capital8 shared
U.S. Venture Partners8 shared
Osage University Partners7 shared
Amzak Health6 shared
Sectoral Asset Management6 shared
Ajax Health6 shared
MiddleGame Ventures5 shared
.406 Ventures5 shared
RA Capital Management5 shared
Gilde Healthcare5 shared
Novo Capital5 shared
Third Point Ventures5 shared
EQT Life Sciences4 shared
Pura Vida Investments4 shared
Endeavour Vision4 shared
Deerfield4 shared
Vivo Capital4 shared
SV Health Investors3 shared
Optum Ventures3 shared
TPG Biotech3 shared
Last updated: 7 October 2026