Protocol Labs primarily focuses its venture capital investments on early-stage computing breakthroughs, with a strong emphasis on Web3, distributed systems, decentralized storage, AI, and open-source technologies. Their strategy involves acting as an innovation network to support startups and accelerate research and development across these frontier technology fields.
Deal activity decreased year-over-year (1 deals in the last 12 months vs 3 prior). Their most common stage is series-a (42% of deals). Average disclosed round size is $28.2M (across 12 rounds with reported amounts).
Portfolio
12
Fund Size
—
Top Stage
Series A
Last 12 Mo
1
Portfolio Breakdown
Stage Distribution
Sector Distribution
Investment Activity
DealsAvg Round Size
Portfolio
12 investments
| Company | Round | Amount | Date |
|---|---|---|---|
| EEnlightra | Series A | $15M | Dec 2025 |
 WeatherXM AG | Series A | $7.7M | May 2024 |
 Prime Intellect | Seed | $5.5M | Apr 2024 |
 Lumino | Pre-Seed | $2.8M | Mar 2024 |
 Zama | Series A | $73M | Mar 2024 |
 Bluesky | Seed | $8M | Jul 2023 |
 Huddle01 | Seed | $2.8M | Apr 2023 |
 QuickNode | Series B | $60M | Jan 2023 |
 thirdweb | Series A | $24M | Aug 2022 |
 CyberConnect | Series A | $15M | May 2022 |
 Unstoppable Domains | Series C | $60M | Mar 2022 |
 ConsenSys | Series C | $65M | Apr 2021 |
Top Co-Investors
Fenbushi Capital2 shared
Coinbase Ventures2 shared
MetaPlanet2 shared
Y Combinator1 shared
Runa Capital1 shared
Pegasus Tech Ventures1 shared
Draper Associates1 shared
Animoca Brands1 shared
Sky9 Capital1 shared
Delphi Digital1 shared
IOSG1 shared
Tribe1 shared
GGV Capital1 shared
Spartan Group1 shared
Amber Group1 shared
Polygon Studios1 shared
SevenX Ventures1 shared
Neo1 shared
Automattic1 shared
Multicoin Capital1 shared
Last updated: 8 March 2026