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    Safeguard Scientifics

    Radnor, United StatesFounded 1953
    safeguardscientifics.comLinkedIn
    HealthcareFintech

    Safeguard Scientifics, Inc. (NYSE: SFE) is a publicly traded venture capital and growth equity firm based in Radnor, Pennsylvania. Founded in 1953, it provides capital and operational expertise to technology-driven businesses in healthcare, financial services, and digital media.

    Average disclosed round size is $17.3M (across 35 rounds with reported amounts).

    Find people at Safeguard Scientifics on Goldilocks AI

    Portfolio

    27

    Fund Size

    —

    Top Stage

    Series C

    Last 12 Mo

    0

    Team

    MH

    Mark Herndon

    Senior Vice President and Chief Financial Officer

    EC

    Eric C. Salzman

    Chief Executive Officer

    GM

    G. Matthew Barnard

    General Counsel and Secretary

    Portfolio Breakdown

    Stage Distribution

    Sector Distribution

    Investment Activity

    DealsAvg Round Size

    Portfolio

    37 investments
    CompanyRoundAmountDate
    Prognos Health logoPrognos HealthGrowth$23MJan 2023
    TT-REX Group, Inc.Series C$40MJan 2022
    Full Measure Education logoFull Measure EducationGrowth$10MJun 2021
    Full Measure Education logoFull Measure EducationGrowth$10MJan 2021
    Syapse logoSyapseSeries D$30MNov 2017
    Trice Medical logoTrice MedicalSeries C$19.3MJun 2017
    Syapse logoSyapseSeed$1.5MJan 2017
    PPropeller HealthSeries C$21.5MOct 2016
    Moxe Health logoMoxe HealthSeries A$5.5MOct 2016
    Aktana logoAktanaSeries A$17.5MJun 2016
    VVelano VascularUnknown$3.5MFeb 2016
    Syapse logoSyapseSeries C$25MJan 2016
    Transactis logoTransactisSeries E$30MJan 2016
    TT-REX Group, Inc.Series B$10MJan 2016
    QuanticMind logoQuanticMindSeries A$10.3MJan 2015
    AAventura, Inc.Series C$6MJan 2015
    CCloudMine, Inc.Series A$5MJan 2015
    TTransactis, Inc.Series D$11MAug 2014
    Transactis logoTransactisSeries D$11MJan 2014
    CCrescendo BioscienceSeries D$28MJan 2013
    PPneuronUnknown$6MJan 2013
    SSpongecellSeries B$10MJan 2012
    PPixelOpticsUnknown$45MApr 2011
    GGood Start Genetics, Inc.Series A$18MSep 2010
    GGood Start GeneticsSeries A$18MSep 2010
    Page 1 of 2

    Top Co-Investors

    Social Capital3 shared
    Roche Venture Fund3 shared
    Ascension Ventures3 shared
    Merck Global Health Innovation Fund3 shared
    The Cigna Group Ventures3 shared
    SR One2 shared
    Amgen Ventures2 shared
    New York Angels2 shared
    StarVest Partners2 shared
    Plug and Play Tech Center2 shared
    Canaan Partners2 shared
    Fulcrum Equity Partners2 shared
    OrbiMed2 shared
    HealthQuest Capital1 shared
    Boldstart Ventures1 shared
    Human Ventures1 shared
    M Ventures1 shared
    Fika Ventures1 shared
    Venture Stars1 shared
    TCA Venture Group1 shared

    Last updated: 8 September 2026