Safeguard Scientifics, Inc. (NYSE: SFE) is a publicly traded venture capital and growth equity firm based in Radnor, Pennsylvania. Founded in 1953, it provides capital and operational expertise to technology-driven businesses in healthcare, financial services, and digital media.
Average disclosed round size is $14.5M (across 56 rounds with reported amounts).
Portfolio
36
Fund Size
—
Top Stage
Series A
Last 12 Mo
0
Team
MH
Mark Herndon
Senior Vice President and Chief Financial Officer
EC
Eric C. Salzman
Chief Executive Officer
GM
G. Matthew Barnard
General Counsel and Secretary
GK
Gary Kurtzman
Managing Director
Portfolio Breakdown
Stage Distribution
Sector Distribution
Investment Activity
DealsAvg Round Size
Portfolio
59 investments
| Company | Round | Amount | Date |
|---|---|---|---|
 Prognos Health | Growth | $23M | Jan 2023 |
 Propeller Health | Series D | $20M | Jun 2018 |
 Prognos | Growth | $23M | Nov 2017 |
 Syapse | Series D | $30M | Nov 2017 |
 Trice Medical | Series C | $19.3M | Jun 2017 |
| Syapse | Seed | $1.5M | Jan 2017 |
| SSpongecell | Series B | $10.5M | Nov 2016 |
 Brickwork | Series A | $5M | Oct 2016 |
| Propeller Health | Series C | $21.5M | Oct 2016 |
 Moxe | Series A | $5.5M | Oct 2016 |
 Medcrypt | Seed | $750K | Sep 2016 |
 Aktana | Series A | $17.5M | Jun 2016 |
| VVelano Vascular | Unknown | $3.5M | Feb 2016 |
| Syapse | Series C | $25M | Jan 2016 |
 Transactis | Series E | $30M | Jan 2016 |
| TT Rex Group Inc | Series B | $10M | Jan 2016 |
| Brickwork | Series A | $5M | Jan 2016 |
| Propeller Health | Series C | $21.5M | Jan 2016 |
| AApprenda | Series D | $24M | Jul 2015 |
 QuanticMind | Series A | $10.3M | Jan 2015 |
| AAventura, Inc. | Series C | $6M | Jan 2015 |
 CloudMine | Series A | $5M | Jan 2015 |
| AApprenda | Unknown | $24M | Jan 2015 |
| Propeller Health | Series B | $14.5M | Sep 2014 |
| Transactis | Series D | $11M | Aug 2014 |
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Top Co-Investors
Social Capital5 shared
SR One4 shared
3M Ventures4 shared
Roche Venture Fund4 shared
The Cigna Group Ventures4 shared
M Ventures3 shared
Excel Venture Management3 shared
Ascension Ventures3 shared
Human Ventures2 shared
Trinity Capital Inc.2 shared
UPMC Enterprises2 shared
TCA Venture Group2 shared
Launchpad Capital2 shared
Broadview Ventures2 shared
Amgen Ventures2 shared
New York Angels2 shared
StarVest Partners2 shared
Plug and Play Tech Center2 shared
Last updated: 20 October 2026