Two River is a New York-based venture capital firm and merchant bank focused on the life science sector. It partners with scientific founders and experienced management to create, finance, and operate companies in biotechnology, oncology, immunotherapy, and synthetic biology.
Their most common stage is series-a (53% of deals). Average disclosed round size is $60.4M (across 10 rounds with reported amounts).
Portfolio
9
Fund Size
—
Top Stage
Series A
Last 12 Mo
0
Team
Portfolio Breakdown
Stage Distribution
Sector Distribution
Investment Activity
DealsAvg Round Size
Portfolio
15 investments
| Company | Round | Amount | Date |
|---|---|---|---|
 ByHeart | Growth | $95M | May 2024 |
| ByHeart | Unknown | — | Jan 2024 |
| ByHeart | Series B | — | Jul 2021 |
| IIconOvir | Series A | $77M | Jan 2021 |
 IconOVir Bio | Series A | $77M | Jan 2021 |
| NNeogene Therapeutics | Series A | $110M | Sep 2020 |
| ByHeart | Series A | $70M | Apr 2020 |
| NNeogene Therapeutics | Seed | — | Jan 2019 |
 Thirty Madison | Series A | $15.3M | Oct 2018 |
 Hubble Contacts | Series A | $16.5M | Mar 2017 |
 Hubble | Series A | $16.5M | Jan 2017 |
| Hubble Contacts | Unknown | $16.5M | Jan 2017 |
| NNeogene Therapeutics | Series A | $110M | — |
| AAndie Swim | Seed | — | — |
 Andie | Seed | — | — |
Top Co-Investors
Polaris Partners9 shared
Gaingels5 shared
Greycroft4 shared
D1 Capital Partners4 shared
OCV Partners4 shared
BECO Capital3 shared
AF Ventures3 shared
Jeito Capital3 shared
Wildcat Capital Management3 shared
FirstMark Capital3 shared
Red Swan Ventures2 shared
Pontifax2 shared
Wellington Management2 shared
Logos Capital2 shared
GV2 shared
Nextech Invest Ltd.2 shared
STEADFAST Capital Ventures1 shared
New Era Capital Partners1 shared
Maveron1 shared
First Round Capital1 shared
Last updated: 20 October 2026