Two River is a New York-based venture capital firm and merchant bank focused on the life science sector. It partners with scientific founders and experienced management to create, finance, and operate companies in biotechnology, oncology, immunotherapy, and synthetic biology.
Their most common stage is series-a (78% of deals). Average disclosed round size is $63.2M (across 7 rounds with reported amounts).
Portfolio
7
Fund Size
—
Top Stage
Series A
Last 12 Mo
0
Team
Portfolio Breakdown
Stage Distribution
Sector Distribution
Investment Activity
DealsAvg Round Size
Portfolio
9 investments
| Company | Round | Amount | Date |
|---|---|---|---|
 ByHeart | Series B | — | Jul 2021 |
 IconOVir Bio | Series A | $77M | Jan 2021 |
| IIconOvir | Series A | $77M | Jan 2021 |
| IIconOvir Bio | Series A | $77M | Jan 2021 |
| NNeogene Therapeutics | Series A | $110M | Sep 2020 |
| ByHeart | Series A | $70M | Apr 2020 |
| NNeogene Therapeutics | Seed | — | Jan 2019 |
 Thirty Madison | Series A | $15.3M | Oct 2018 |
 Hubble Contacts | Series A | $16.5M | Mar 2017 |
Top Co-Investors
Polaris Partners7 shared
Wellington Management3 shared
Logos Capital3 shared
GV3 shared
Greycroft2 shared
BECO Capital2 shared
D1 Capital Partners2 shared
Red Swan Ventures2 shared
OCV Partners2 shared
Jeito Capital2 shared
Nextech2 shared
STEADFAST Capital Ventures1 shared
New Era Capital Partners1 shared
Maveron1 shared
First Round Capital1 shared
Northzone1 shared
AF Ventures1 shared
Gaingels1 shared
Alphabet Inc.1 shared
Pontifax1 shared
Last updated: 8 September 2026