Polaris Partners (formerly Polaris Venture Partners) is a Boston-based venture capital firm founded in 1996, focused on healthcare, biotechnology, and technology companies. The firm has backed more than 400 companies across its ten funds, investing from seed and early stage through growth equity.
Deal activity increased 900% year-over-year (10 deals in the last 12 months). Average disclosed round size is $61.7M (across 225 rounds with reported amounts).
Portfolio
188
Fund Size
—
Top Stage
Series B
Last 12 Mo
13
Team
TM
Terry McGuire
Founding Partner
AS
Amy Schulman
Managing Partner
Alan Crane
Entrepreneur Partner
CL
Chen-Ee Lee
Partner
Portfolio Breakdown
Stage Distribution
Sector Distribution
Investment Activity
DealsAvg Round Size
Portfolio
251 investments
| Company | Round | Amount | Date |
|---|---|---|---|
| SSoufflé Therapeutics | Series A | — | Aug 2026 |
| UUpDoc, Inc. | Seed | $18M | Jun 2026 |
| UUpDoc, Inc. | Strategic | — | Jun 2026 |
| CCrossbow | Series B | — | Mar 2026 |
 Tropic | Series C | $105M | Mar 2026 |
| TTropic Biosciences | Bridge | $105M | Mar 2026 |
 KASH | Pre-Seed | $2M | Feb 2026 |
| TTRexBio, Inc. | Series C | $50M | Jan 2026 |
 EpiBiologics | Series B | — | Jan 2026 |
 Trex Bio | Unknown | $50M | Jan 2026 |
| KKash Bot | Pre-Seed | $2M | Jan 2026 |
 Zag Bio | Series A | $80M | Oct 2025 |
 Cirrus Therapeutics | Seed | $11M | Oct 2025 |
 Fire1 | Unknown | $120M | Jan 2025 |
 Noema Pharma | Series B | — | Dec 2024 |
 ByHeart | Growth | $95M | May 2024 |
 Jibe | Seed | $875K | Mar 2024 |
| FFreenome | Growth | $254M | Feb 2024 |
 Cohere Health | Series C | $50M | Feb 2024 |
 Seres Therapeutics | Series E | $113M | Jan 2024 |
 Vico Therapeutics | Series B | $60M | Jan 2024 |
 Lore | Unknown | $80M | Jan 2024 |
 Matter Neuroscience | Seed | $26M | Jan 2024 |
 Noema | Series B | — | Jan 2024 |
 Tome Biosciences | Series B | $213M | Dec 2023 |
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Top Co-Investors
GV26 shared
ARCH Venture Partners22 shared
The Invus Group, LLC17 shared
Alexandria Venture Investments14 shared
OrbiMed13 shared
Omega Funds11 shared
Temasek Holdings (Private) Limited10 shared
RA Capital Management10 shared
Forbion10 shared
Sofinnova Partners10 shared
Eli Lilly and Company10 shared
Venrock10 shared
Leaps by Bayer9 shared
Mirae Asset9 shared
Bessemer Venture Partners9 shared
Perceptive Advisors9 shared
Cormorant Asset Management9 shared
ArrowMark Partners9 shared
Flare Capital Partners8 shared
General Catalyst8 shared
Last updated: 9 September 2026