Polaris Partners (formerly Polaris Venture Partners) is a Boston-based venture capital firm founded in 1996, focused on healthcare, biotechnology, and technology companies. The firm has backed more than 400 companies across its ten funds, investing from seed and early stage through growth equity.
Deal activity increased 1200% year-over-year (13 deals in the last 12 months). Average disclosed round size is $55.1M (across 346 rounds with reported amounts).
Portfolio
230
Fund Size
—
Top Stage
Series B
Last 12 Mo
13
Team
TM
Terry McGuire
Founding Partner
AS
Amy Schulman
Managing Partner
Alan Crane
Entrepreneur Partner
CL
Chen-Ee Lee
Partner
Portfolio Breakdown
Stage Distribution
Sector Distribution
Investment Activity
DealsAvg Round Size
Portfolio
388 investments
| Company | Round | Amount | Date |
|---|---|---|---|
 Tropic | Series C | $105M | Dec 2026 |
| SSouffle Therapeutics | Series A | — | Aug 2026 |
| UUpDoc, Inc. | Seed | $18M | Jun 2026 |
| UUpDoc, Inc. | Strategic | — | Jun 2026 |
| CCrossbow | Series B | — | Mar 2026 |
 Tropic | Series C | $105M | Mar 2026 |
| Tropic | Series C | $105M | Mar 2026 |
 Tropic Biosciences | Bridge | $105M | Mar 2026 |
 Kash | Pre-Seed | $2M | Feb 2026 |
| TTRexBio, Inc. | Series C | $50M | Jan 2026 |
 EpiBiologics | Series B | — | Jan 2026 |
 Trex Bio | Unknown | $50M | Jan 2026 |
| CCrossbow | Series B | $77M | Jan 2026 |
 IgniteData | Series A | $11M | Nov 2025 |
 ZagBio | Series A | $80M | Oct 2025 |
 Cirrus Therapeutics | Seed | $11M | Oct 2025 |
| VVolastra | Seed | $44M | Jan 2025 |
 FIRE1 | Unknown | $120M | Jan 2025 |
 Cohere Health | Series C | $90M | Jan 2025 |
 Noema Pharma | Series B | — | Dec 2024 |
 ByHeart | Growth | $95M | May 2024 |
 Jibe | Seed | $875K | Mar 2024 |
 Freenome | Growth | $254M | Feb 2024 |
| Cohere Health | Series C | $50M | Feb 2024 |
 Seres Therapeutics | Series E | $113M | Jan 2024 |
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Top Co-Investors
GV37 shared
ARCH Venture Partners33 shared
Alexandria Venture Investments24 shared
F-Prime Capital22 shared
The Invus Group, LLC22 shared
OrbiMed21 shared
Temasek Holdings (Private) Limited18 shared
General Catalyst18 shared
Pfizer Ventures17 shared
Leaps by Bayer16 shared
Omega Funds16 shared
Bessemer Venture Partners15 shared
RA Capital Management15 shared
Flagship Pioneering15 shared
.406 Ventures14 shared
Samsara BioCapital14 shared
Forbion14 shared
Eli Lilly and Company14 shared
Sofinnova Partners13 shared
Venrock12 shared
Last updated: 7 October 2026