Polaris Partners (formerly Polaris Venture Partners) is a Boston-based venture capital firm founded in 1996, focused on healthcare, biotechnology, and technology companies. The firm has backed more than 400 companies across its ten funds, investing from seed and early stage through growth equity.
Deal activity increased 250% year-over-year (7 deals in the last 12 months). Average disclosed round size is $71.9M (across 163 rounds with reported amounts).
Portfolio
133
Fund Size
—
Top Stage
Series B
Last 12 Mo
9
Team
TM
Terry McGuire
Founding Partner
AS
Amy Schulman
Managing Partner
Alan Crane
Entrepreneur Partner
CL
Chen-Ee Lee
Partner
Portfolio Breakdown
Stage Distribution
Sector Distribution
Investment Activity
DealsAvg Round Size
Portfolio
176 investments
| Company | Round | Amount | Date |
|---|---|---|---|
| SSoufflé Therapeutics | Series A | — | Aug 2026 |
| CCrossbow | Series B | — | Mar 2026 |
 Tropic | Series C | $105M | Mar 2026 |
 KASH | Pre-Seed | $2M | Feb 2026 |
| TTRexBio, Inc. | Series C | $50M | Jan 2026 |
 EpiBiologics | Series B | $107M | Jan 2026 |
 Trex Bio | Unknown | $50M | Jan 2026 |
 Zag Bio | Series A | $80M | Oct 2025 |
 Cirrus Therapeutics | Seed | $11M | Oct 2025 |
 Fire1 | Unknown | $120M | Jan 2025 |
 Noema Pharma | Series B | — | Dec 2024 |
 ByHeart | Growth | $95M | May 2024 |
 Jibe | Seed | $875K | Mar 2024 |
 Cohere Health | Series C | $50M | Feb 2024 |
 Seres Therapeutics | Series E | $113M | Jan 2024 |
 Vico Therapeutics | Series B | $60M | Jan 2024 |
 Lore | Unknown | $80M | Jan 2024 |
 Tome Biosciences | Series B | $213M | Dec 2023 |
 Triveni Bio | Series A | $92M | Oct 2023 |
 65LAB | Unknown | — | Oct 2023 |
 Simon Data | Series D | $54M | Aug 2023 |
| CCrossbow Therapeutics, Inc. | Series A | $80M | Jul 2023 |
 Candesant Biomedical | Series B | $35M | Jun 2023 |
| Fire1 | Unknown | $25M | Mar 2023 |
 Paratus Sciences | Series D | $100M | Feb 2023 |
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Top Co-Investors
GV24 shared
ARCH Venture Partners15 shared
Alexandria Venture Investments11 shared
The Invus Group, LLC10 shared
OrbiMed10 shared
Eli Lilly and Company9 shared
Omega Funds9 shared
RA Capital Management8 shared
Cormorant Asset Management8 shared
Bessemer Venture Partners7 shared
Perceptive Advisors7 shared
Frazier Healthcare Partners7 shared
ArrowMark Partners7 shared
Longitude Capital7 shared
Pfizer Ventures7 shared
Venrock7 shared
Khosla Ventures6 shared
Deerfield6 shared
Flare Capital Partners6 shared
Last updated: 7 September 2026