Polaris Partners (formerly Polaris Venture Partners) is a Boston-based venture capital firm founded in 1996, focused on healthcare, biotechnology, and technology companies. The firm has backed more than 400 companies across its ten funds, investing from seed and early stage through growth equity.
Deal activity increased 600% year-over-year (14 deals in the last 12 months). Average disclosed round size is $56.3M (across 378 rounds with reported amounts).
Portfolio
241
Fund Size
—
Top Stage
Series B
Last 12 Mo
14
Team
TM
Terry McGuire
Founding Partner
AS
Amy Schulman
Managing Partner
Alan Crane
Entrepreneur Partner
CL
Chen-Ee Lee
Partner
Portfolio Breakdown
Stage Distribution
Sector Distribution
Investment Activity
DealsAvg Round Size
Portfolio
425 investments
| Company | Round | Amount | Date |
|---|---|---|---|
 Tropic | Series C | $105M | Dec 2026 |
| SSouffle Therapeutics | Series A | — | Aug 2026 |
| UUpDoc, Inc. | Seed | $18M | Jun 2026 |
| UUpDoc, Inc. | Strategic | — | Jun 2026 |
| CCrossbow | Series B | — | Mar 2026 |
 Tropic | Series C | $105M | Mar 2026 |
| Tropic | Series C | $105M | Mar 2026 |
 Tropic Biosciences | Bridge | $105M | Mar 2026 |
 Kash | Pre-Seed | $2M | Feb 2026 |
| TTRexBio, Inc. | Series C | $50M | Jan 2026 |
 EpiBiologics | Series B | — | Jan 2026 |
 Trex Bio | Unknown | $50M | Jan 2026 |
| CCrossbow | Series B | $77M | Jan 2026 |
 IgniteData | Series A | $11M | Nov 2025 |
 ZagBio | Series A | $80M | Oct 2025 |
 Pelage Pharmaceuticals | Series B | $120M | Oct 2025 |
 Cirrus Therapeutics | Seed | $11M | Oct 2025 |
 Verdiva Bio | Series A | $410M | Jan 2025 |
| VVolastra | Seed | $44M | Jan 2025 |
 FIRE1 | Unknown | $120M | Jan 2025 |
 Cohere Health | Series C | $90M | Jan 2025 |
 Noema Pharma | Series B | — | Dec 2024 |
 ByHeart | Growth | $95M | May 2024 |
 Jibe | Seed | $875K | Mar 2024 |
 Capstan Therapeutics | Series B | $175M | Mar 2024 |
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Top Co-Investors
GV42 shared
ARCH Venture Partners37 shared
Alexandria Venture Investments31 shared
The Invus Group, LLC27 shared
OrbiMed26 shared
F-Prime Capital25 shared
RA Capital Management21 shared
General Catalyst20 shared
Temasek Holdings (Private) Limited19 shared
Pfizer Ventures18 shared
Omega Funds18 shared
Flagship Pioneering18 shared
Leaps by Bayer17 shared
Forbion16 shared
Sofinnova Partners16 shared
.406 Ventures15 shared
Bessemer Venture Partners15 shared
Eli Lilly and Company15 shared
Samsara BioCapital14 shared
Fidelity Investments14 shared
Last updated: 20 October 2026