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    .406 Ventures logo

    .406 Ventures

    Boston, Massachusetts, United StatesFounded 2005
    www.406ventures.comLinkedIn
    HealthcareData & AnalyticsAICybersecurity

    .406 Ventures is a Boston-based early-stage venture capital firm that partners with entrepreneurs to build category-defining companies. The firm focuses on investments across healthcare, data + AI, and cybersecurity, leading or co-leading early-stage rounds.

    Deal activity increased 150% year-over-year (10 deals in the last 12 months). Average disclosed round size is $26.5M (across 160 rounds with reported amounts).

    Find people at .406 Ventures on Goldilocks AI

    Portfolio

    92

    Fund Size

    $265M

    Top Stage

    Series A

    Last 12 Mo

    10

    Team

    LD

    Liam Donohue

    Co-Founder and Managing Partner

    SM

    So-June Min

    Managing Director of Operations

    GB

    Graham Brooks

    Partner

    GD

    Greg Dracon

    Partner

    PA

    Payal Agrawal Divakaran

    Partner

    TH

    Trip Hofer

    Venture Partner

    KT

    Kathryn Taylor Reddy

    Principal

    KW

    Kevin Wang

    Principal

    RR

    Rebecca Redfield

    Senior Associate

    ED

    Esther Dominguez

    General Counsel

    JS

    Joanna Skoler Gilman

    Chief Marketing and Communications Officer

    JS

    Joe SantaBarbara

    Chief Financial Officer

    Portfolio Breakdown

    Stage Distribution

    Sector Distribution

    Investment Activity

    DealsAvg Round Size

    Portfolio

    172 investments
    CompanyRoundAmountDate
    Mindgard logoMindgardSeries A$30MAug 2026
    InStride Health logoInStride HealthSeries C$30MJun 2026
    InStride logoInStrideSeries C$30MJun 2026
    Relai logoRelaiPre-Seed$12MJun 2026
    Big Health logoBig HealthUnknown$23.7MFeb 2026
    Valerie Health logoValerie HealthSeries A$30MDec 2025
    FamilyWell logoFamilyWellSeries A$8MNov 2025
    Familywell Health logoFamilywell HealthSeries A$8MNov 2025
    IgniteData logoIgniteDataSeries A$11MNov 2025
    Diana Health logoDiana HealthSeries C—Sep 2025
    Bluebird Kids Health logoBluebird Kids HealthUnknown$31.5MMar 2025
    Rad Security logoRad SecuritySeries A$14MFeb 2025
    NNema HealthSeries A$14.5MJan 2025
    Nema logoNemaSeries A$14.5MJan 2025
    Valerie Health logoValerie HealthSeries A$30MJan 2025
    Humata Health logoHumata HealthUnknown$25MJun 2024
    Indico Data logoIndico DataSeries B$19MJun 2024
    indico logoindicoUnknown$19MJun 2024
    OOncoverycareSeed$4.5MMay 2024
    Wayspring logoWayspringUnknown—May 2024
    InStride Health logoInStride HealthSeries B$30MMar 2024
    InStride Health logoInStride HealthSeries B$30MMar 2024
    Familywell Health logoFamilywell HealthSeed$4.3MFeb 2024
    Mindgard logoMindgardSeed$8MJan 2024
    InStride Health logoInStride HealthSeries B$30MJan 2024
    Page 1 of 7

    Top Co-Investors

    F-Prime Capital23 shared
    General Catalyst15 shared
    Optum Ventures15 shared
    Polaris Partners14 shared
    Valtruis12 shared
    Techstars10 shared
    Accomplice10 shared
    Mass General Brigham Ventures10 shared
    BoxGroup9 shared
    Khosla Ventures9 shared
    Bain Capital Ventures9 shared
    Deerfield8 shared
    Flare Capital Partners8 shared
    Sandbox Industries8 shared
    Temasek Holdings (Private) Limited7 shared
    Longitude Capital7 shared
    GreyMatter Capital7 shared
    RRE Ventures7 shared
    The Blue Venture Fund6 shared
    Scale Venture Partners6 shared

    Last updated: 7 October 2026