Polaris Partners (formerly Polaris Venture Partners) is a Boston-based venture capital firm founded in 1996, focused on healthcare, biotechnology, and technology companies. The firm has backed more than 400 companies across its ten funds, investing from seed and early stage through growth equity.
Deal activity increased 267% year-over-year (11 deals in the last 12 months). Average disclosed round size is $61.6M (across 321 rounds with reported amounts).
Portfolio
205
Fund Size
—
Top Stage
Series B
Last 12 Mo
11
Team
TM
Terry McGuire
Founding Partner
AS
Amy Schulman
Managing Partner
Alan Crane
Entrepreneur Partner
CL
Chen-Ee Lee
Partner
Portfolio Breakdown
Stage Distribution
Sector Distribution
Investment Activity
DealsAvg Round Size
Portfolio
364 investments
| Company | Round | Amount | Date |
|---|---|---|---|
 Tropic | Series C | $105M | Dec 2026 |
| SSouffle Therapeutics | Series A | — | Aug 2026 |
| UUpDoc, Inc. | Seed | $18M | Jun 2026 |
| UUpDoc, Inc. | Strategic | — | Jun 2026 |
| CCrossbow | Series B | — | Mar 2026 |
 Tropic | Series C | $105M | Mar 2026 |
| TTropic Biosciences | Bridge | $105M | Mar 2026 |
 Kash | Pre-Seed | $2M | Feb 2026 |
| TTRexBio, Inc. | Series C | $50M | Jan 2026 |
 EpiBiologics | Series B | — | Jan 2026 |
 Trex Bio | Unknown | $50M | Jan 2026 |
| KKash Bot | Pre-Seed | $2M | Jan 2026 |
| CCrossbow | Series B | $77M | Jan 2026 |
 ZagBio | Series A | $80M | Oct 2025 |
 Cirrus Therapeutics | Seed | $11M | Oct 2025 |
 eGenesis | Series D | $191M | Aug 2025 |
 Cardiac Dimensions | Series E | $53M | Mar 2025 |
| VVolastra | Seed | $44M | Jan 2025 |
 FIRE1 | Unknown | $120M | Jan 2025 |
 Cohere Health | Series C | $90M | Jan 2025 |
 Noema Pharma | Series B | — | Dec 2024 |
 ByHeart | Growth | $95M | May 2024 |
 Jibe | Seed | $875K | Mar 2024 |
 Freenome | Growth | $254M | Feb 2024 |
| Cohere Health | Series C | $50M | Feb 2024 |
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Top Co-Investors
GV36 shared
ARCH Venture Partners34 shared
Alexandria Venture Investments26 shared
F-Prime Capital22 shared
The Invus Group, LLC22 shared
OrbiMed20 shared
Leaps by Bayer17 shared
Temasek Holdings (Private) Limited16 shared
Pfizer Ventures16 shared
RA Capital Management15 shared
Omega Funds15 shared
General Catalyst14 shared
Bessemer Venture Partners14 shared
.406 Ventures13 shared
Khosla Ventures13 shared
Samsara BioCapital13 shared
Forbion13 shared
Flare Capital Partners11 shared
Mirae Asset11 shared
Sofinnova Partners11 shared
Last updated: 19 September 2026