Investment Firms in San Mateo, California, United States
Situated in the heart of Silicon Valley, it serves as a significant hub for venture capital, particularly for companies in the growth stages of Series A and Series B. The city's ecosystem is distinguished by its strong concentration on artificial intelligence, fintech, and biotechnology sectors. Its venture capital presence, largely established in the last two decades, benefits from deep integration with the broader regional network of innovation and talent.
San Mateo, California, United States's investment landscape is shaped by AI, with 62% of its 29 investment firms focused on this sector. The most active by portfolio size are Draper Associates, Franklin Templeton, and Sierra Ventures.
AI dominates the investment landscape in San Mateo, with 62% of investment firms focused on this sector.
San Mateo is a particularly strong hub for early-stage investing, with over 90% of investment firms active at the Seed or Pre-Seed stage.
Last updated: 9 September 2026
Investment Firms
29
Total Investments
1,366
Top Sector
AI
Top Stage
Series A
Top Investment Sectors in San Mateo
The most popular sector focus among San Mateo investment firms is AI, with 18 investment firms (62%) investing in the space. This is followed by Healthcare (14), Enterprise Software (13), Fintech (11), SaaS (10).
Investment Stages in San Mateo
San Mateo investment firms are most active at the Series A stage (28 investment firms). This is followed by Series B (27), Seed (26), Series C (16), Growth (14).
Draper Associates
San Mateo, California, United States
200 investments
Seed, Series A
AI, Robotics & Automation, Crypto & Web3 …
Franklin Templeton
San Mateo, California, United States
135 investments
Series E, Series B
Enterprise Software, Defense & Space, Data & Analytics
Sierra Ventures
San Mateo, California, United States
125 investments
Series A, Seed
AI, Enterprise Software, Data & Analytics …
Emergence Capital
San Mateo, California, United States
120 investments
Series B, Series A
Enterprise Software, SaaS, AI
Boost VC
San Mateo, California, United States
92 investments
Seed, Series A
AI, Biotech & Life Sciences, Climate & Energy …
DFJ Growth
San Mateo, California, United States
87 investments
Series B, Series C
AI, Biotech & Life Sciences, Robotics & Automation …
Draper Nexus
San Mateo, California, United States
65 investments
Series A, Seed
Enterprise Software, SaaS, Cybersecurity …
Forgepoint Capital
San Mateo, California, United States
56 investments
Series B, Series A
Cybersecurity, AI, Infrastructure & Cloud
WestBridge Capital
San Mateo, California, United States
55 investments
Series B, Series A
Consumer, E-Commerce & Marketplace, Education …
PeakSpan Capital
San Mateo, California, United States
45 investments
Series B, Series A
SaaS, Data & Analytics, AI …
Emergent Ventures
San Mateo, California, United States
37 investments
Seed, Series A
AI, Enterprise Software, SaaS …
GS Futures
San Mateo, California, United States
36 investments
Seed, Series A
Robotics & Automation, Construction, Climate & Energy …
SemperVirens Venture Capital
San Mateo, California, United States
35 investments
Series A, Series B
AI, Healthcare, Fintech …
Fall Line Capital
San Mateo, California, United States
34 investments
Seed, Series A
Food & Agriculture
Sunstone Partners
San Mateo, California, United States
33 investments
Series A, Series B
Enterprise Software, AI, Data & Analytics …
Draper Dragon
San Mateo, California, United States
33 investments
Seed, Series A
Crypto & Web3, AI, Healthcare …
GingerBread Capital
San Mateo, California, United States
30 investments
Series A, Series B
Consumer, Education, Enterprise Software …
Mohr Davidow Ventures
San Mateo, California, United States
29 investments
Series C, Series A
Enterprise Software, Healthcare, Biotech & Life Sciences …
Portfolia
San Mateo, California, United States
28 investments
Series A, Seed
Healthcare, Biotech & Life Sciences, Climate & Energy …
Union Labs
San Mateo, California, United States
16 investments
Seed, Series A
AI, Robotics & Automation, Climate & Energy …
Sumeru Equity Partners
San Mateo, California, United States
15 investments
Growth, Series E
SaaS, Data & Analytics, Education …
Guidewire Software
San Mateo, California, United States
11 investments
Series A, Series D
Insurance, Enterprise Software, AI …
Fortitude Ventures
San Mateo, California, United States
10 investments
Seed, Series A
AI, Robotics & Automation
Peninsula Ventures
San Mateo, California, United States
8 investments
Series B, Series C
SaaS, Enterprise Software, Infrastructure & Cloud …
Acorn Pacific Ventures
San Mateo, California, United States
7 investments
Series A, Seed
Enterprise Software, AI, Healthcare …
Grep VC
San Mateo, California, United States
7 investments
Seed, Pre Seed
Robotics & Automation, AI, Hardware & Semiconductors
Zynga
San Mateo, California, United States
6 investments
Seed, Series B
Gaming
Tidemark
San Mateo, California, United States
6 investments
Series F, Growth
SaaS, Enterprise Software, AI
Path
San Mateo, California, United States
5 investments
Series A, Seed
Fintech, SaaS, Consumer …