Investment Firms in San Mateo, California, United States
Situated in the heart of Silicon Valley, it serves as a significant hub for venture capital, particularly for companies in the growth stages of Series A and Series B. The city's ecosystem is distinguished by its strong concentration on artificial intelligence, fintech, and biotechnology sectors. Its venture capital presence, largely established in the last two decades, benefits from deep integration with the broader regional network of innovation and talent.
San Mateo, California, United States's investment landscape is shaped by AI, with 50% of its 12 investment firms focused on this sector. The most active by portfolio size are Franklin Templeton, Draper Associates, and Boost VC.
AI dominates the investment landscape in San Mateo, with 50% of investment firms focused on this sector.
San Mateo has a long history of venture capital, with Franklin Templeton operating since 1947.
Last updated: 13 March 2026
Investment Firms
12
Total Investments
290
Top Sector
AI
Top Stage
Series A
Top Investment Sectors in San Mateo
The most popular sector focus among San Mateo investment firms is AI, with 6 investment firms (50%) investing in the space. This is followed by Fintech (5), Biotech & Life Sciences (5), Crypto & Web3 (5), Defense & Space (5).
Investment Stages in San Mateo
San Mateo investment firms are most active at the Series A stage (10 investment firms). This is followed by Series B (9), Seed (7), Series C (6), Series D (3).
Franklin Templeton
San Mateo, California, United States
80 investments
Series E, Series B
Fintech, Enterprise Software, Data & Analytics …
Draper Associates
San Mateo, California, United States
62 investments
Series A, Seed
Crypto & Web3, Defense & Space, Fintech …
Boost VC
San Mateo, California, United States
32 investments
Seed, Series A
Defense & Space, Crypto & Web3, Fintech …
Semper Virens
San Mateo, California, United States
24 investments
Series A, Series B
Healthcare, PropTech, HR & Talent …
Celesta Capital
San Mateo, California, United States
19 investments
Series B, Series A
AI, Healthcare, Cybersecurity …
DNX
San Mateo, California, United States
17 investments
Series A, Series B
Cybersecurity, Robotics & Automation, Consumer …
GS Futures
San Mateo, California, United States
13 investments
Series A, Seed
Climate & Energy, HR & Talent, Gaming …
Draper Dragon
San Mateo, California, United States
12 investments
Seed, Series A
Crypto & Web3, AI, Gaming …
Inventus Capital
San Mateo, California, United States
10 investments
Series A, Series C
Healthcare, Consumer, Defense & Space …
Delphi Ventures
San Mateo, California, United States
9 investments
Seed, Series A
Crypto & Web3, AI, Gaming …
FalconX
San Mateo, California, United States
6 investments
Seed, Growth
Cybersecurity, Mobility & Transportation, Education …
Recruit Strategic Partners
San Mateo, California, United States
6 investments
Series D, Series B
Fintech, Education, Developer Tools …