Investment Firms in San Mateo, California, United States
Situated in the heart of Silicon Valley, it serves as a significant hub for venture capital, particularly for companies in the growth stages of Series A and Series B. The city's ecosystem is distinguished by its strong concentration on artificial intelligence, fintech, and biotechnology sectors. Its venture capital presence, largely established in the last two decades, benefits from deep integration with the broader regional network of innovation and talent.
San Mateo, California, United States's investment landscape is shaped by AI, with 60% of its 30 investment firms focused on this sector. The most active by portfolio size are Draper Associates, Franklin Templeton, and Emergence Capital.
AI dominates the investment landscape in San Mateo, with 60% of investment firms focused on this sector.
San Mateo is a particularly strong hub for early-stage investing, with over 93% of investment firms active at the Seed or Pre-Seed stage.
Last updated: 20 October 2026
Investment Firms
30
Total Investments
1,639
Top Sector
AI
Top Stage
Series A
Top Investment Sectors in San Mateo
The most popular sector focus among San Mateo investment firms is AI, with 18 investment firms (60%) investing in the space. This is followed by Healthcare (15), Enterprise Software (13), Fintech (11), SaaS (10).
Investment Stages in San Mateo
San Mateo investment firms are most active at the Series A stage (29 investment firms). This is followed by Seed (28), Series B (25), Series C (19), Growth (14).
Draper Associates
San Mateo, California, United States
219 investments
Seed, Series A
AI, Robotics & Automation, Crypto & Web3 …
Franklin Templeton
San Mateo, California, United States
167 investments
Series B, Series E
Enterprise Software, Defense & Space, Data & Analytics
Emergence Capital
San Mateo, California, United States
141 investments
Series B, Series A
Enterprise Software, SaaS, AI
Sierra Ventures
San Mateo, California, United States
139 investments
Series A, Seed
AI, Enterprise Software, Data & Analytics …
Boost VC
San Mateo, California, United States
110 investments
Seed, Pre Seed
AI, Biotech & Life Sciences, Climate & Energy …
DFJ Growth
San Mateo, California, United States
108 investments
Series B, Series C
AI, Biotech & Life Sciences, Robotics & Automation …
DNX Ventures
San Mateo, California, United States
86 investments
Series A, Seed
Enterprise Software, SaaS, Cybersecurity …
WestBridge Capital
San Mateo, California, United States
67 investments
Series B, Series A
Consumer, E-Commerce & Marketplace, Education …
Forgepoint Capital
San Mateo, California, United States
62 investments
Series B, Series A
Cybersecurity, AI, Infrastructure & Cloud
PeakSpan Capital
San Mateo, California, United States
49 investments
Series B, Series A
SaaS, Data & Analytics, AI …
GingerBread Capital
San Mateo, California, United States
46 investments
Series A, Series B
Consumer, Education, Enterprise Software …
Mohr Davidow Ventures
San Mateo, California, United States
45 investments
Series A, Series B
Enterprise Software, Healthcare, Biotech & Life Sciences …
SemperVirens Venture Capital
San Mateo, California, United States
44 investments
Series A, Series B
AI, Healthcare, Fintech …
GS Futures
San Mateo, California, United States
44 investments
Series A, Seed
Robotics & Automation, Construction, Climate & Energy …
Draper Dragon
San Mateo, California, United States
44 investments
Seed, Series A
Crypto & Web3, AI, Healthcare …
Emergent Ventures
San Mateo, California, United States
43 investments
Seed, Series A
AI, Enterprise Software, SaaS …
Fall Line Capital
San Mateo, California, United States
37 investments
Seed, Series A
Food & Agriculture
Sunstone Partners
San Mateo, California, United States
33 investments
Series A, Series B
Enterprise Software, AI, Data & Analytics …
Portfolia
San Mateo, California, United States
29 investments
Series A, Seed
Healthcare, Biotech & Life Sciences, Climate & Energy …
Sumeru Equity Partners
San Mateo, California, United States
19 investments
Growth, Series C
SaaS, Data & Analytics, Education …
Union Labs
San Mateo, California, United States
17 investments
Seed, Series A
AI, Robotics & Automation, Climate & Energy …
Acorn Pacific Ventures
San Mateo, California, United States
17 investments
Series A, Seed
Enterprise Software, AI, Healthcare …
Fortitude Ventures
San Mateo, California, United States
12 investments
Seed, Series A
AI, Robotics & Automation
Peninsula Ventures
San Mateo, California, United States
12 investments
Series B, Series A
SaaS, Enterprise Software, Infrastructure & Cloud …
Guidewire Software
San Mateo, California, United States
12 investments
Series A, Series B
Insurance, Enterprise Software, AI …
Path
San Mateo, California, United States
10 investments
Series A, Seed
Fintech, SaaS, Consumer …
Grep VC
San Mateo, California, United States
8 investments
Seed, Pre Seed
Robotics & Automation, AI, Hardware & Semiconductors
Zynga
San Mateo, California, United States
7 investments
Seed, Series A
Gaming
Tidemark
San Mateo, California, United States
7 investments
Series B, Series F
SaaS, Enterprise Software, AI
1955 Capital
San Mateo, California, United States
5 investments
Series B, Series A
Climate & Energy, Biotech & Life Sciences, Food & Agriculture …